| Title | [Study of ALAD and VDR gene polymorphisms associated with lead nephrotoxicity susceptibility] | | Author(s) | Wang A, Wang Q, Song Q, Xu J | | Institution | Ningbo Municipal Center For Disease Control and Prevention, Ningbo 315010, China. | | Source | Wei Sheng Yan Jiu 2009 May; 38(3):326-9. | | Abstract | OBJECTIVE: To explore lead nephrotoxicity associated with delta-aminolevulinic acid dehydratase, vitamin D receptor gene polymorphism as well as joint effect of gene-gene, gene-environment.
METHODS: 233 occupational lead-exposed workers were involved in this study. Then blood lead was detected as lead exposure biomarker. Urinary N-acetyl-beta-D-glucosamindase and beta2-microglobin of those workers were measured as biomarkers of nephrotoxicity. PCR-RFLP method was used for gene polymorphism analysing.
RESULTS: Lead exposure concentration was higher than national limit, NAG acticity were (2.12 +/- 0.07) U/mmol Cr in workers with ALAD1-2/ALAD2-2 genotype and (1.73 +/- 0.03) U/mmol Cr in workers with ALAD1-1 genotype (P < 0.05). In the same condition, beta2-MG were (20.94 +/- 1.12) microg/mmol Cr in workers with VDR-Bb genotype and (15.28 +/- 0.09) microg/mmol Cr in workers with VDR-bb genotype (P = 0.01). Analysis of logistic regression confirmed that lead exposure and high blood lead as well as combined effect of gene-environment were responsible for lead nephrotoxicity in workers (OR = 6.58, 2.41, 3.01).
CONCLUSION: Polymorphisms of ALAD and VDR gene may play an important role in lead nephrotoxicity in high lead-exposed workers. Joint effect of gene-environment could be involved in lead nephrotoxicity in workers. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19548578 |
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